Symbol
Name
ID

Il1r1
interleukin 1 receptor, type I
MGI:96545

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Inflammation of the large intestine	Acne	Psoriasiform dermatitis	Palmoplantar pustulosis	Skin rash	Osteomyelitis	Autoimmunity
Disease(s) Associated with IL1R1	Inflammation of the large intestine	Acne	Psoriasiform dermatitis	Palmoplantar pustulosis	Skin rash	Osteomyelitis	Autoimmunity
chronic recurrent multifocal osteomyelitis
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

impaired neutrophil chemotaxis

decreased T cell proliferation

enlarged spleen

decreased eosinophil cell number

decreased neutrophil cell number

decreased T cell number

abnormal spleen morphology

abnormal neutrophil physiology

decreased immunoglobulin level

abnormal microglial cell activation

increased circulating interleukin-1 beta level

decreased circulating interleukin-18 level

increased circulating interleukin-18 level

decreased circulating interleukin-6 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

decreased circulating serum amyloid protein level

decreased susceptibility to type IV hypersensitivity reaction

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

decreased susceptibility to autoimmune diabetes

decreased susceptibility to experimental autoimmune uveoretinitis

decreased susceptibility to induced arthritis

increased susceptibility to induced arthritis

abnormal inflammatory response

osteomyelitis

increased susceptibility to bacterial infection

increased susceptibility to bacterial infection induced morbidity/mortality

sepsis

Availability

Mouse Genotype

Il1r1^{em1(IMPC)Ccpcz}/Il1r1^{em1(IMPC)Ccpcz}

Il1r1^em1Qizh/Il1r1^em1Qizh

Il1r1^tm1Imx/Il1r1^tm1Imx

Il1r1^tm1Quan/Il1r1^tm1Quan

Il1r1^tm1Roml/Il1r1^tm1Roml

Il1r1^tm1Quan/Il1r1^tm1Quan
Tg(Tek-cre)12Flv/0 (conditional)

Il1r1^tm1Quan/Il1r1^tm1Quan
Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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